Glucosamine Sulfate Glucosamine is an amino saccharide that research suggests stimulates chondrocytes, supports GAG synthesis, incorporates sulfur into cartilage, induces HA production, and modulates prostaglandin (e.g., PGE2) synthesis.[16-18] Most of the scientific research done on glucosamine has been performed using glucosamine sulfate. Oral doses of 1,500 mg/d show clinical benefits in joint mobility and comfort.[16,19] It is postulated that lower doses may nourish the joint tissues, especially in combination with chondroitin sulfate. Several studies confirm that the benefits of combining glucosamine sulfate and chondroitin sulfate outweigh taking them alone.*[20-22]